Table S1.
Sensitivity and specificity of FIT for AN according to FIT cutoff and mean of daily maximum temperatures during sample travel
| FIT cutoff (µg/g) | Maximum temperature (°C) | Sensitivity (N=267 with AN)
|
Specificity (N=2,603 without AN)
|
||
|---|---|---|---|---|---|
| TP/NAN | % (95% CI) | TN/Nno AN | % (95% CI) | ||
| 10 | <10 | 46/87 | 52.9 (41.9–63.7) | 707/805 | 87.8 (85.4–90.0) |
| 10–19 | 55/100 | 55.0 (44.7–65.0) | 886/1019 | 86.9 (84.7–89.0) | |
| 20–24 | 30/56 | 53.6 (39.7–67.0) | 436/484 | 90.1 (87.1–92.6) | |
| ≥ 25 | 14/24 | 58.3 (36.6–77.9) | 252/295 | 85.4 (80.9–89.2) | |
|
| |||||
| 15 | <10 | 38/87 | 43.7 (33.1–54.7) | 750/805 | 93.2 (91.2–94.8) |
| 10–19 | 47/100 | 47.0 (36.9–57.2) | 938/1019 | 92.1 (90.2–93.6) | |
| 20–24 | 23/56 | 41.1 (28.1–55.0) | 450/484 | 93.0 (90.3–95.1) | |
| ≥ 25 | 10/24 | 41.7 (22.1–63.4) | 273/295 | 92.5 (88.9–95.3) | |
|
| |||||
| 17 | <10 | 38/87 | 43.7 (33.1–54.7) | 759/805 | 94.3 (92.5–95.8) |
| 10–19 | 46/100 | 46.0 (36.0–56.3) | 949/1019 | 93.1 (91.4–94.6) | |
| 20–24 | 23/56 | 41.1 (28.1–55.0) | 451/484 | 93.2 (90.6–95.3) | |
| ≥ 25 | 9/24 | 37.5 (18.8–59.4) | 276/295 | 93.6 (90.1–96.1) | |
|
| |||||
| 20 | <10 | 35/87 | 40.2 (29.9–51.3) | 767/805 | 95.3 (93.6–96.6) |
| 10–19 | 44/100 | 44.0 (34.1–54.3) | 963/1019 | 94.5 (92.9–95.8) | |
| 20–24 | 22/56 | 39.3 (26.5–53.2) | 459/484 | 94.8 (92.5–96.6) | |
| ≥ 25 | 7/24 | 29.2 (12.6–51.1) | 277/295 | 93.9 (90.5–96.3) | |
|
| |||||
| 25 | <10 | 33/87 | 37.9 (27.7–49.0) | 775/805 | 96.3 (94.7–97.5) |
| 10–19 | 41/100 | 41.0 (31.3–51.3) | 978/1019 | 96.0 (94.6–97.1) | |
| 20–24 | 19/56 | 33.9 (21.8–47.8) | 465/484 | 96.1 (93.9–97.6) | |
| ≥ 25 | 7/24 | 29.2 (12.6–51.1) | 282/295 | 95.6 (92.6–97.6) | |
Note: Italic text represents results for the cutoff recommended by the manufacturer.
Abbreviations: AN, advanced neoplasia (colorectal cancer or advanced adenoma); FIT, fecal immunochemical test; NAN, number of participants with advanced neoplasm; Nno AN, number of participants without advanced neoplasm; TN, true negative; TP, true positive; µg/g, microgram hemoglobin per gram of stool.