Evolution of the adhered fraction of Gantrez in either a folded shape as nanoparticles or dissolved in an aqueous solution after the oral administration of 1 mL aqueous dispersion containing 10 mg copolymer. Each value represents the mean of the results of four experiments. Plot: x-axis represents the adhered fraction (mg); y-axis represents the different gut segments (Sto: stomach; I1, I2, I3, I4: small intestinal segments; Ce: caecum); z-axis represents the time post-administration (0.5, 1, 3 and 8 h).