Table 2.

Chemical agents targeting mitochondrial dynamics in ischemic stroke

Agents	Proposed mechanisms	Refs.
Drp1 siRNA	Inhibition of fission via DRP1 down-regulation	[55-57, 61]
Drp1 cysteine mutation	Inhibition of fission by preventing S-nitrosylation induced Drp1 activation	[59]
Ginkgolide K	Inhibition of fission by increasing Drp1 phosphorylation and inhibiting Drp1 recruitment	[60]
mdivi-1	Inhibition of fission by inhibiting the GTPase activity of Drp1	[55, 61]
P110	Inhibition of fission by inhibiting Drp1 enzyme activity and blocking Drp1/Fis1 interaction	[62, 63]
Mfn2 overexpression	Promotion of fusion	[49, 50]