Table 1.
Serum and urine electrolytes in progranulin knockout (Grn-/-) and wildtype (Grn+/+) female mice.
| Genotype | Wks | ml/24h | g | Urine (mmol/l) | Serum (mmol/l) | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| Age | Drink | BW | Crea | Ca | Cl | K | Mg | Na | P | Glc | Urea | Ca | Cl | K | Mg | Na | P | mosmol/kg | |
| Grn-/- | 42.3 | 7.5 | 25.5 | 1.768 | 4.1 | 50.6 | 105.7 | 3.4 | 37 | 11.7 | 13.1 | 10 | 2.3 | 111 | 4.3 | 0.9 | 146 | 2.0 | 315.1 |
| Grn-/- | 42.3 | 9.0 | 26.6 | 1.800 | 3.4 | 55.1 | 96.2 | 3.5 | 42 | 12.5 | 14.5 | 9.6 | 2.3 | 111 | 4.9 | 1.1 | 145 | 2.0 | 314.1 |
| Grn-/- | 42.3 | 3.3 | 25.2 | 1.774 | 2.6 | 29.1 | 74.9 | 0.8 | 31 | 10.1 | 12.7 | 9.7 | 2.3 | 112 | 4.9 | 1.0 | 149 | 1.8 | 320.4 |
| Grn-/- | 42.3 | 3.8 | 25.4 | 1.298 | 3.2 | 41.9 | 85.4 | 3.0 | 40 | 12.4 | 14.0 | 8.9 | 2.3 | 108 | 3.8 | 1.0 | 143 | 2.0 | 308.9 |
| Grn-/- | 42.3 | 2.7 | 26.0 | 1.544 | 5.1 | 55.9 | 87.8 | 3.3 | 61 | 2.0 | 13.0 | 9.2 | 2.4 | 110 | 4.1 | 1.1 | 147 | 2.3 | 316.2 |
| Grn-/- | 46.4 | 8.7 | 24.8 | 0.413 | 0.4 | 17.2 | 28.2 | 0.6 | 16 | 9.2 | 16.3 | 7.3 | 2.3 | 112 | 4.1 | 0.9 | 146 | 2.0 | 315.6 |
| Grn-/- | 51.1 | 6.0 | 27.2 | 1.091 | 2.1 | 45.2 | 74.6 | 0.3 | 41 | 10.9 | 15.6 | 7.2 | 2.4 | 114 | 4.0 | 0.9 | 149 | 2.0 | 320.8 |
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| Grn+/+ | 50.7 | 2.6 | 24.0 | 3.400 | 6.3 | 38.9 | 154.2 | 3.4 | 38 | 14.4 | 14.9 | 7.1 | 2.4 | 111 | 3.7 | 1.0 | 147 | 2.0 | 316.0 |
| Grn+/+ | 48.6 | 1.1 | 23.7 | 2.831 | 3.2 | 37.2 | 120.2 | 3.4 | 45 | 14.7 | 13.1 | 10.2 | 2.4 | 112 | 4.2 | 1.0 | 150 | 2.0 | 323.3 |
| Grn+/+ | 48.6 | 1.2 | 24.2 | 1.475 | 4.3 | 57.8 | 114.9 | 3.4 | 56 | 13.8 | 8.8 | 12.1 | 2.4 | 112 | 5.2 | 0.9 | 148 | 1.4 | 316.9 |
| Grn+/+ | 44.7 | 0.8 | 24.0 | 1.581 | 5.6 | 40.4 | 98.0 | 3.4 | 47 | 6.1 | 11.4 | 6.8 | 2.3 | 112 | 4.3 | 0.9 | 149 | 1.6 | 316.2 |
| Grn+/+ | 43.6 | 0.3 | 23.3 | 2.288 | 2.6 | 48.2 | 215.9 | 3.5 | 35 | 9.9 | 13.5 | 7.4 | 2.4 | 109 | 4.3 | 0.9 | 146 | 1.8 | 312.9 |
| Grn+/+ | 43.7 | 4.7 | 24.1 | 1.704 | 3.5 | 39.6 | 88.1 | 3.3 | 28 | 13.3 | - | 8.8 | 2.4 | 112 | 3.9 | 1.0 | 148 | 2.0 | - |
| Means | |||||||||||||||||||
| Grn-/- | 44.1 | 5.9 | 25.8 | 1.384 | 3.0 | 42.1 | 78.9 | 2.1 | 38.3 | 9.8 | 14.2 | 8.8 | 2.3 | 111.1 | 4.3 | 1.0 | 146.4 | 2.0 | 315.9 |
| Grn+/+ | 46.6 | 1.8 | 23.9 | 2.213 | 4.2 | 43.7 | 131.9 | 3.4 | 41.5 | 12.0 | 12.3 | 8.7 | 2.4 | 111.3 | 4.3 | 1.0 | 148.0 | 1.8 | 317.1 |
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| Grn-/-SD | 3.5 | 2.6 | 0.8 | 0.506 | 1.5 | 14.3 | 25.0 | 1.5 | 13.5 | 3.6 | 1.4 | 1.1 | 0.0 | 1.9 | 0.4 | 0.1 | 2.1 | 0.1 | 4.0 |
| Grn+/+SD | 3.0 | 1.6 | 0.3 | 0.775 | 1.4 | 7.9 | 47.0 | 0.1 | 9.9 | 3.4 | 2.3 | 2.1 | 0.0 | 1.2 | 0.5 | 0.1 | 1.4 | 0.3 | 3.8 |
| t-test P | 0.196 | 0.007 | 0.0003 | 0.041 | 0.154 | 0.820 | 0.025 | 0.057 | 0.640 | 0.290 | 0.118 | 0.907 | 0.053 | 0.835 | 0.902 | 0.416 | 0.155 | 0.083 | 0.6178 |
Abbreviations: Wks, weeks; BW, body weight; Crea, creatinine; Ca, calcium; Cl, chloride; K, potassium; Mg, magnesium; Na, sodium; P, anorganic phosphate, Glc, glucose; SD, standard deviation; t-test 2 sided unpaired