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Mechanism of epithelial-to-mesenchymal transition in colorectal cancer. External stimuli or mutations in cancer cells induce epithelial-to-mesenchymal transition (EMT), where epithelial cells undergo phenotypic changes and transit into an invasive mesenchymal cell state. Mesenchymal cells invade the systemic circulation and undergo a mesenchymal-to-epithelial transition (MET) in distant organs, thus facilitating metastasis.
