Fig. 3.

Secretome and RNA-seq analysis of 16HBE^rs35699176 show altered profiles in adhesion molecules. a Analysis of protein–protein interaction networks demonstrates higher secretion in the 16HBE^rs35699176 cell line of proteins involved in cell metabolism regulation and exosome pathways. Red ellipses represent proteins detected directly by mass spectrometry while the blue rectangles are proteins induced by the bioinformatics modelling within each network. b Functional category enrichment analysis of the differentially expressed and secreted proteins in 16HBE and 16HBE^rs35699176 bronchial epithelial with and without A. fumigatus challenge. Experiments were performed in biological replicates. Gene Ontology analyses were performed using strings. Statistical significance was calculated using strings