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. 2018 Sep 20;8:14143. doi: 10.1038/s41598-018-32495-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vivo implantation and histological analysis of the microgrooved DEX-BCP-Col composite scaffolds. (a) A schematic of in vitro cell culture and in vivo implantation of the scaffolds. (b) Gross appearance of the implants after 8 weeks of implantation. (c) Photomicrographs of H&E staining of decalcified cross-sections of the implants after 8 weeks of implantation. The photomicrographs in the second line are the magnified ones of the first line. The photomicrographs in the third and fourth lines are the magnified ones at peripheral and central regions of the photomicrographs shown in the second line. Yellow triangles indicate new blood vessels. Green triangles indicate new bone formation.