Figure 5. Knockdown of LINC00473 promotes the tumor regression of CRC in vivo.
HCT116/Taxol cells with/without LINC00473 knockdown were subcutaneously injected in rear flank of nude mice (six per group) and then the mice were treated with 6 mg/kg Taxol (i.p). (A) The mean tumor size (mm3) and (B) tumor weight (g) was analyzed. (C) The expression of miR-15a in tumor tissues was estimated by Q-PCR. (D) The expression of Ki-67 was determined by immunohistochemistry and (E) the expressions of apoptosis-related Bcl-2, caspase-3, BAX and MDR-related LRP and MDR1 in tumor tissues were determined by WB. **P<0.01, data represent the means ± s.d.