Figure 1.

Limb anomalies due to fetal causes (chromosomal aberrations).

a) Bilateral cutaneous syndactyly of the little and ring fingers (arrow) and right little finger clinodactyly (arrow) in a short broad hand of a Down syndrome child (trisomy 21).

b) Left preaxial polydactyly (arrow) in a newborn male with Edward’s syndrome (trisomy 18). Note the malformed low-set and posteriorly rotated ears, the micrognathia, the clenched hand, and the overlapping fingers.

c) Left postaxial polydactyly (arrow) in a newborn male with partial trisomy 13 (13q+). Other dysmorphic features include bulging forehead, blepharophimosis, deep-set eyes, depressed nasal bridge, long philtrum, thin upper lip, and pectus excavatum.