Figure 5.

Limb anomalies due to environmental causes.

a) A newborn with sirenomelia (due to vascular disruption) where both lower limbs and feet are fused, absent external genitalia and imperforate anus.

b) A newborn with general vascular disruption presented with bilateral limb amputation (transverse reduction defect), absent right thumb and index finger, right radial hypoplasia (radial ray defect), absent external genitalia, and blue colored skin.

c) Bilateral gangrene of the leg and foot due to abnormal circulation in one of a triplet.