Table 2.
Results of GEE models on OSA individuals and non-OSA matched controls.
| Variable | Model 1: All psychotropic drugs | Model 2: Antidepressants | Model 3: Anxiolytics | Model 4: Hypnotics | ||||
|---|---|---|---|---|---|---|---|---|
| Effect† (p) | 95% CI | Effect† (p) | 95% CI | Effect† (p) | 95% CI | Effect† (p) | 95% CI | |
| Group | ||||||||
| Matched control | ref. | — | ref. | — | ref. | — | ref. | — |
| OSA | + 4% (NS) | [−2%, + 11%] | + 19% (***) | [ + 12%, + 27%] | −14% (***) | [−21%,−5%] | −9% (**) | [−17%,−1%] |
| Year | ||||||||
| 0 | ref. | — | ref. | — | ref. | — | ref. | — |
| 1 | −9% (***) | [−11%,−7%] | −8% (***) | [−11%,−5%] | −8% (***) | [−11%,−5%] | −11% (***) | [−14%,−7%] |
| 2 | −14% (***) | [−16%,−11%] | −14% (***) | [−17%,−10%] | −15% (***) | [−18%,−11%] | −12% (***) | [−16%,−8%] |
| 3 | −17% (***) | [−20%,−15%] | −16% (***) | [−20%,−12%] | −21% (***) | [−24%,−17%] | −16% (***) | [−20%,−11%] |
| Group × Year | ||||||||
| OSA × 1 | −1% (NS) | [−6%, + 4%] | 0% (***) | [−6%, + 6%] | −4% (NS) | [−11%, + 4%] | −1% (NS) | [−10%, + 9%] |
| OSA × 2 | + 1% (NS) | [−5%, + 7%] | + 4% (***) | [−4%, + 13%] | −4% (NS) | [−13%, + 6%] | −5% (NS) | [−14%, + 6%] |
| OSA × 3 | + 1% (NS) | [−5%, + 8%] | + 3% (***) | [−6%, + 12%] | + 4% (NS) | [−7%, + 15%] | −8% (NS) | [−19%, + 4%] |
GEE: generalized estimating equations, CI: confidence interval, p: P-value, OSA: obstructive sleep apnoea. NS: not significant, *p-value < 10%, **p-value < 5%, ***p-value < 1%. A logarithm function was used as link function. The estimated intercepts are not shown in the table. †The multiplicative effect was computed from a transformation of the estimated coefficients β: Effect = (1 - β) × 100.