Table 5.

Multivariable analysis of subgroup opinions relevant to the impact of MSI/IHC results on timing of surgery and extent of colonic resection

Statement for Evaluation	Demographic variables	Respondents answering “True” (Percentage)	Odds Ratio (95% confidence interval)
“Abnormal MSI/IHC/Germline testing results can affect extent of colonic resection.”	Gastroenterology (GI) subspecialty
	General GI	175 (64.8%)	1.00
	GI Oncology Specializations	12 (80.0%)	1.04 (0.26, 4.25)
	All other GI Specializations	59 (71.1%)	0.98 (0.55, 1.74)
	Urban/rural location
	Urban	210 (67.5%)	0.93 (0.50, 1.74)
	Rural	36 (63.2%)	1.00
	Practice setting
	Academic Center	80 (80.8%)	2.41 (1.25, 4.64)
	Non-academic Center	168 (62.7%)	1.00
	Career Stage
	Fellows in training	35 (76.1%)	1.33 (0.60, 2.97)
	In practice from 0 to 10 years	88 (72.7%)	1.57 (0.94, 2.61)
	In practice from 11+ years	122 (60.7%)	1.00
	Familiarity with the guideline
	Familiar	115 (70.6%)	1.30 (0.73, 2.33)
	Unsurea	77 (62.6%)	0.91 (0.50, 1.66)
	Unfamiliarb	56 (65.9%)	1.00
“If MSI/IHC testing is ordered on CRC biopsy, surgery should wait to perform resection until after results have returned”	Gastroenterology (GI) subspecialty
	General GI	80 (29.0%)	1.00
	GI Oncology Specializations	8 (53.3%)	1.54 (0.49, 4.89)
	All other GI Specializations	29 (31.9%)	1.04 (0.59, 1.83)
	Urban/rural location
	Urban	107 (33.0%)	1.72 (0.84, 3.54)
	Rural	11 (18.6%)	1.00
	Practice setting
	Academic Center	39 (36.8%)	1.39 (0.77, 2.51)
	Non-academic Center	79 (28.6%)	1.00
	Career stage
	Fellows in training	13 (27.7%)	0.70 (0.31, 1.57)
	In practice from 0 to 10 years	44 (34.1%)	1.26 (0.76, 2.07)
	In practice from 11+ years	60 (29.0%)	1.00
	Familiarity with the guideline
	Familiar	65 (40.1%)	2.36 (1.25, 4.45)
	Unsurea	35 (28.0%)	1.49 (0.76, 2.91)
	Unfamiliarb	17 (20.0%)	1.00

^aUnsure means they are not clear on whether they are aware of the applicable guidelines or not

^bUnfamiliar means providers are not well versed with current guidelines