Fig. 2. MiR-873-5p correlates with liver fibrosis development through the regulation of GNMT in the liver.

Hepatic GNMT-miR-873-5p expression and correlation in a cohort of cirrhotic patients (N = 16) (a) and circulating miR-873-5p in cirrhotic patients (N = 35) (b). (c) Circulating miR-873-5p levels in cholestatic (PBC/PSC) patients (41) and its correlation with fibrosis (LSM, kPa). (d) GNMT levels in cholestatic patients (N = 64). (e) Correlation between circulating miR-873-5p and hepatic GNMT in cholestatic patients (N = 19). (f) Correlation between circulating miR-873-5p and hepatic GNMT with fibrotic stage in cholestatic patients, respectively. Data normalized as fold change vs. control. Error bars represent the means ± SEM. Statistical significance was determined by the Student’s t-test or ANOVA when more than two groups were compared. p < 0.05*; p < 0.01**; p < 0.001***