Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Plausible model in which hypoxia/oxidative stress in the placenta activates a disintegrin and metalloproteinase-17 (ADAM17), leading to the shedding and activation of TNF-α and the subsequent increased expression/activity of matrix metalloproteinase (MMP)-1 and MMP-7 and likely other MMPs that impair vascular remodeling and promote preeclampsia.
