FIG 5.

Chromosomal map of M. tuberculosis H37Rv TA systems. TA systems are annotated according to the information in the Tuberculist database, except for VapBC45 (Rv2018-Rv2019), VapBC49 (Rv3181c-Rv3180c), VapBC50 (Rv3750c-Rv3749c), HigBA2 (Rv2022c-Rv2021c), HigBA3 (Rv3182-Rv3183), YefM/YoeB (Rv3357-Rv3358), and MazEF10 (Rv0298-Rv0299). Most of the TA systems depicted here probably belong to type II, except for those marked with an asterisk, which are putative type IV systems. For each system, the functionality in E. coli (Ec), M. smegmatis (Msm), and M. tuberculosis (Mtb) is depicted as follows: red indicates inhibition of growth, gray indicates no inhibition of growth, and white indicates that the system was not tested. The 10 most commonly induced TA systems in drug-tolerant persister cells are highlighted by a dark blue background. (Reproduced from reference 404 with permission.)