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. 2018 Jul 18;31(4):e00021-18. doi: 10.1128/CMR.00021-18

TABLE 3.

Examples of altered immune responses by M. tuberculosis strain HN878 relative to the CDC1551 or H37Rv strain

Immune response HN878-induced difference(s) vs H37Rv or CDC1551 References
Innate Altered interactions with pattern recognition receptors (e.g., Toll-like receptors) 29, 247, 248
Reduced activation of monocytes, macrophages, and dendritic cells
Adaptive Raised levels of CD4+/CD25+/FoxP3+/CD223+/IL-10+ regulatory T cells 27, 29, 249
Cytokine Induction of type I IFNs 27, 29, 249
Induction of TH2 cytokines IL-4 and IL-13
Rapid repression of an initial spike in TH1 cytokines TNF-α, IL-6, IL-12, and IFN-γ