TABLE 3.
Examples of altered immune responses by M. tuberculosis strain HN878 relative to the CDC1551 or H37Rv strain
Immune response | HN878-induced difference(s) vs H37Rv or CDC1551 | References |
---|---|---|
Innate | Altered interactions with pattern recognition receptors (e.g., Toll-like receptors) | 29, 247, 248 |
Reduced activation of monocytes, macrophages, and dendritic cells | ||
Adaptive | Raised levels of CD4+/CD25+/FoxP3+/CD223+/IL-10+ regulatory T cells | 27, 29, 249 |
Cytokine | Induction of type I IFNs | 27, 29, 249 |
Induction of TH2 cytokines IL-4 and IL-13 | ||
Rapid repression of an initial spike in TH1 cytokines TNF-α, IL-6, IL-12, and IFN-γ |