TABLE 3.

Examples of altered immune responses by M. tuberculosis strain HN878 relative to the CDC1551 or H37Rv strain

Immune response	HN878-induced difference(s) vs H37Rv or CDC1551	References
Innate	Altered interactions with pattern recognition receptors (e.g., Toll-like receptors)	29, 247, 248
	Reduced activation of monocytes, macrophages, and dendritic cells
Adaptive	Raised levels of CD4+/CD25+/FoxP3+/CD223+/IL-10+ regulatory T cells	27, 29, 249
Cytokine	Induction of type I IFNs	27, 29, 249
	Induction of TH2 cytokines IL-4 and IL-13
	Rapid repression of an initial spike in TH1 cytokines TNF-α, IL-6, IL-12, and IFN-γ