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. 2018 Sep 20;8:14116. doi: 10.1038/s41598-018-32349-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The B. divergens free-merozoite recognizes and invades the human erythrocyte. The panels above show time-lapse image sequences of four B. divergens merozoites stained with MitoTracker (green fluorescent) that are exiting in 9 s from an infected human erythrocyte stained with PKH26 (red fluorescent). One of the merozoites identifies a new erythrocyte and establishes a tight irreversible connection with the erythrocyte plasma membrane causing a deep invagination and deformation to the erythrocyte at 48–75 s. The total internalization of the free merozoite occurs at ≈93 s. The parasite is surrounded by the red fluorescent erythrocyte membrane-derived parasitophorous vacuolar membrane after invasion. Simultaneously, the panels below show the PKH26 fluorescence around the infected and non-infected erythrocytes but also around the invasive parasite within the erythrocyte. Time-lapse imaging was captured every 1 s. The time-lapse between each frame is indicated in seconds.