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. 2018 Aug 10;73(10):2797–2805. doi: 10.1093/jac/dky264

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© The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please email: journals.permissions@oup.com.

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Figure 3. — Antibiotic-resistant mutants fail to colonize the host. (a) Colonization of nasal cavities of C57BL/6 mice 7 days after being inoculated with 150, 1500 or 15 000 cfu of B. bronchiseptica RB50 WT (circles) or the p1 antibiotic-resistant mutant EmR1 (squares). The dotted line represents the limit of detection. (b) Colonization profiles of B. bronchiseptica WT (RB50), antibiotic-resistant p1 mutants (EmR1–EmR4) and Bvg^– (RB54) in mouse nasal cavities 7 days after being inoculated with 15 000 cfu of each strain. ***P < 0.0001 (P values of <0.05 were considered statistically significant). The dotted line represents the limit of detection.