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. 2018 Aug 10;73(10):2797–2805. doi: 10.1093/jac/dky264

Figure 4.

Figure 4.

In vitro phenotype comparisons of B. bronchiseptica RB50 and erythromycin-resistant mutant derivatives. (a) Cytotoxicity of B. bronchiseptica RB50 WT and p1 resistant mutants against RAW 264.7 macrophages. Relative percentage cytotoxicity of WT and mutant bacteria against cultured RAW 264.7 mouse macrophages exposed to the bacterial strains for 4 h at 37°C (moi 10:1). The bars represent the mean ± SEM (n = 3). (b) Adherence of WT B. bronchiseptica RB50 and mutant bacteria EmR1 and Δfha to A459 human lung epithelial cells. (c) Induction of cytokines from RAW 264.7 mouse macrophages by B. bronchiseptica and antibiotic-resistant mutants from p1. The bars represent the mean ± SEM (n = 3). *P < 0.05; **P < 0.001; ***P < 0.0001 (P values of <0.05 were considered statistically significant).