Table 3.
Nucleotide/amino acid changes in selected mcr-3/MCR-3 allelesa
| Alleleb | Identified inc | Nucleotide differences from mcr-3.1 or mcr-3.7 | Amino acid differences from MCR-3.1 or MCR-3.7 |
|---|---|---|---|
| 3.1 | E. coli, K. pneumoniae, Salmonella Typhimurium, Shigella sonnei | — | — |
| 3.2 | E. coli, Shigella | C1463T | Thr488Ile |
| 3.4 | K. pneumoniae, S. sonnei | G1118T | Gly373Val |
| 3.5 | E. coli, Shigella | A67G, C1370A, C1463T | Met23Val, Ala457Glu, Thr488Ile |
| 3.11 | E. coli | G1118T, CA1402-3AC | Gly373Val, Gln468Thr |
| 3.7 | Aeromonas media | — | — |
| 3.12 | E. coli | T380C + 9 other differences | Val127Ala |
a
mcr-3.3 and mcr-3.6–mcr-3.9 have been found in various Aeromonas spp. (see Figure S1a) and have 34–100 nucleotide changes from mcr-3.1, while the MCR-3.3 and MCR-3.6–MCR-3.9 proteins have 11–27 amino acid differences from MCR-3.1. mcr-3.10 has been found in Aeromonas caviae, E. coli and Proteus mirabilis and has 19 nucleotide changes from mcr-3.1 and MCR-3.10 has 7 amino acid changes from MCR-3.1.
b
Allele numbers assigned by NCBI are in bold.
c
Species/genera in which each allele has been detected to date.