Table 4.

Nucleotide/amino acid changes in mcr-4/MCR-4 alleles from species other than Shewanella

Allelea	Identified inb	Nucleotide differences from mcr-4.1	Amino acid differences from MCR-4.1
4.1	E. coli, Salmonella spp.	—	—
4.2	E. coli, Salmonella Typhimurium	A992G	Gln331Arg
4.3c	Enterobacter cloacae	T536G, G706T	Val179Gly, Val236Phe
4.4	E. coli	C613A, A992G	His205Asn, Gln331Arg
4.5	E. coli	C329T, A992G	Pro110Leu, Gln331Arg
4.6d	Salmonella Kedougou	not available	Val236Phe

^aAllele numbers assigned by NCBI are in bold.

^bSpecies/genera in which each allele has been detected to date.

^cOriginally named mcr-4.2.

^dOriginally named mcr-4.3, but initially published without an INSDC entry,³⁷ so not included in Figure 1.