. 2018 Jul 24;73(10):2721–2728. doi: 10.1093/jac/dky256

Table 1.

Steady-state kinetic parameters (K_m and k_cat) for EFdA-MP and dAMP incorporation by HIV-1 RTs from different subtypes

Subtype	k_cat (m⁻¹)		K_m.dNTP (nM)		k_cat/K_m.dNTP (nM⁻¹ m⁻¹)		Comparative efficiency^a
Subtype	dATP	EFdA-TP	dATP	EFdA-TP	dATP	EFdA-TP	Comparative efficiency^a
HIV-1B	16 ± 2	19 ± 3	49 ± 4	21 ± 3	0.33	0.90	2.8
HIV-1C	8 ± 3	9 ± 2	39 ± 2	27 ± 3	0.21	0.33	1.6
01_AE	19 ± 2	22 ± 3	44 ± 3	16 ± 4	0.43	1.38	3.2
02_AG	22 ± 3	18 ± 4	55 ± 5	17 ± 3	0.40	1.01	2.5

Comparative efficiency is the ratio of the incorporation efficiency (k_cat/K_m) of EFdA-MP over that of dAMP [(k_cat/K_m)_EFdA-MP/(k_cat/K_m)_dAMP].