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. 2018 Sep 20;9(10):967. doi: 10.1038/s41419-018-0992-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Cartoon representation of (a) apo NRZ (light blue). Helices are labelled as α1–8, with the view being into the hydrophobic groove formed by α2–5. b Cartoon representation of Mcl-1 (olive)⁴⁹. c CNP058 (orange)⁵¹, the closest structural homolog from viral pro-survival Bcl-2 proteins for NRZ. d NRZ (green) in complex with zBad BH3 motif (hot pink). e Bcl-x_L (blue) in complex with Bad BH3 motif (yellow)⁵⁰, f Mcl-1 (brown) in complex with Bim (magenta) BH3 motif⁴⁹. All views in b–f are as in a