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. 2018 Sep 20;9(10):967. doi: 10.1038/s41419-018-0992-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Comparison of the backbone structures of NRZ and NRZ: zBad BH3 complex. a Cartoon representation of apo NRZ (light blue) superimposed onto NRZ: zBad BH3 complex (green). The view is into the canonical hydrophobic binding groove formed by α2–5. b Close up view of NRZ helix α4, which is shifted by 3 Å from its original position in the apo NRZ structure upon zBad BH3 motif binding, thus enlarging the binding groove