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. 2018 Sep 20;9(10):970. doi: 10.1038/s41419-018-0961-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a mRNA correlations of Rab3A, OGT, COX8A, COX7C, COX6A1, COX5B, COX8A, and COX4I1 in 442 primary HCC tumors of TCGA (n = 442 biologically independent patient samples). b, c mRNA and protein levels of COX8A, COX7C, COX6A1, COX5B, COX5A, and COX4I1 in PLC/PRF/5 cells with OGT and/or Rab3A expression. d The OCR curves in parental PLC/PRF/5, Rab3A + , shCOX8A, and Rab3A + shCOX8A cells treated with oligomycin, FCCP, and rotenone/antimycin A. e MitoSOX Red staining of PLC/PRF/5 cells with indicated treatments was analyzed by flow cytometry. f Transwell invasion assay for PLC/PRF/5 cells with indicated treatments. Six independent experiments were performed for each assay. g The OCR curves in OGT-knockdowned Hep3B, shOGT + Rab3A + , shOGT + shCOX8A, and shOGT + Rab3A + shCOX8A cells treated with oligomycin, FCCP, and rotenone/antimycin A. h MitoSOX Red staining of HeprB cells with indicated treatments was analyzed by flow cytometry, and the invasive ability was analyzed by transwell invasion assays under indicated treatments. i The schematic diagram describing the function of Rab3A and O-GlcNAcylation in HCC metastasis. Six independent experiments were performed for each assay. *p < 0.05, **p < 0.01, ***p < 0.001; NS, not significant