Table 1.
Characteristics of studies included in the review.
| Identification | Location | Inclusion period | Population | Inclusion criteria | TFT a | Measurement device, company | Sampling time. Day | Age, yr | Male, % | Mortality | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| %, | Time of measurement | ||||||||||
| Cui 2007 | China | 2004–2005 | 22 | Severe sepsis, Septic shock | T4,T3, TSH | NR | D1, D3, D5 | 65.6 ± 17.7 | 81% | 36% (8/22) | In-hospital |
| Gonzalez* 2016 | Spain | NR | 50 | Severe sepsis, Septic shock | fT4, fT3 | ECLIA (Roche) | D3 | 75.5 (59.7–80.0) | 62% | 30% (15/50) | In-hospital |
| Hosny 2015 | Egypt | 2013–2014 | 80 | Sepsis, Severe sepsis, Septic shock | fT4, fT4, TSH | ELISA (BioCheck) | D5 | Survivors: 46.3 ± 13.8 non-survivors: 65.7 ± 14.2 | 75% | 48% (39/80) | In-hospital |
| Leo-Sanz 1997 | Spain | NR | 27 | Septic shock | T4, T3 | RIA (Behringwerke AG,Marburg) | D5 | 50 ± 19 | 66% | 44% (12/27) | In-hospital |
| Mangas 1990 | Spain | NR | 37 | Sepsis | T4, T3, TSH | RIA (Diagnostic Products Corporation) | During admission | 57 ± 17.8 | 100% | 40% (15/37) | In-hospital |
| Meyer 2011 | Switzerland | 11 yr | 103 | SIRS, Sepsis, Severe sepsis, Septic shock | T3, fT4 | ECLIA (Roche) | D1, D2, Discharge day | 59(46–68) | 54% | 23% (24/103) | In-hospital |
| Sumita | USA | NR | 41 | Sepsis | T4, T3, fT4, fT3, TSH | RIA (Dainabot) | D1 | Male 31(17–77) Female 10(22–77) | 75% | 56% (23/41) | In-hospital |
| Todd 2012 | USA | 2 yr | 231 | Sepsis Severe sepsis, Septic shock | T4, T3, TSH | NR | During admission | 59 ± 3 | 43% | 17%(41/231) | In-hospital |
Abbreviations: D, day of admission; ECLIA, electro-chemiluminescence immunoassay; ELISA, enzyme-linked immunosorbent assay; fT3, free triiodothyronine; fT4, free thyroxine; NR, not reported; T3, triiodothyronine; T4, thyroxine; RIA, radioimmunoassay; SIRS, systematic inflammatory response syndrome; TFT, thyroid function test; TSH, thyroid-stimulating hormone. *Abstract only. aT4(µg/dL), T3(ng/dl), fT4(ng/dL), fT3(pg/ml), TSH(µIU/ml). bAge was presented as median (interquartile range) or mean ± standard deviation.