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. 2018 Sep 20;8:14087. doi: 10.1038/s41598-018-32568-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of Dezocine on κ agonist U50,488H-induced antinociception. (A) Dezocine did not affect U50,488H-produced antinociceptive effects. (B) In the presence of μ antagonist β-FNA, pretreatment with Dezocine significantly decreased the antinociceptive effects produced by U50,488 H. Mice were injected with U50,488 H and Dezocine with or without β-FNA. After 15 min, the antinociception was measured in the abdominal constriction test. Data are presented as mean ± SEM from at least 10 mice. *p < 0.05 in comparison with U50,488 H + β-FNA group.