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. 2017 May 24;313(3):F767–F780. doi: 10.1152/ajprenal.00683.2016

Fig. 2.

Fig. 2.

Tissue injury scores and serum creatinine concentrations comparing Mif−/− vs WT mice with or without recombinant MIF-2/D-DT treatment. A and C: acute tubular injury following sham surgery or 30-min bilateral renal ischemia in Mif−/− (A, blue bars) or Cd74-null (C, green) mice compared with WT mice. B: serum creatinine levels in mice as in (A) at 24 or 48 h following I/R. D: acute tubular injury following bilateral renal ischemia at 48 or 72 h in mice as in A with administration of MIF-2/D-DT at the time of the release of ischemia and every 12 h thereafter (hashed bars) or left untreated (clear bars). Mif−/− mice showed significant delay in tubular cell regeneration at 48 and 72 h after I/R (blue bars). MIF-2/D-DT treatment significantly improved the tissue injury score in Mif−/− and WT animals (hatched bars). **P < 0.05; ***P < 0.01; ****P < 0.001; n = 6–8 mice in each experimental group.