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Flk1ST−/− mice have a mild concentrating defect. A–C: histograms of data collected from 24-h water intake and urine collections revealed mild trends for increased water intake (A), increased urine output (B), and lower osmolarity (C) in mutants vs. control animals, consistent with concentrating defects in mutants. *P < 0.05; controls: n = 16; mutants: n = 17.
