Fig. 2.

Urinary ATP does not increase in HKα₁^−/− mice fed a high-Na⁺ diet in contrast to controls where ATP is proportionally related to dietary Na⁺ intake. A: effect of dietary Na⁺ on urinary ATP in wild-type (WT) and HKα₁^−/− mice. WT, n = 8–20; HKα₁^−/−, n = 24 *P < 0.05 vs. 0.32% [Na⁺] same genotype. †P < 0.05 vs. WT, same condition. B: ENaC in HKα₁^−/− mice responds normally to exogenous ATP. P_o in HKα₁^−/− mice is shown before and after addition of ATP (100 μM) as individual experiments and means ± SE; n = 16. *P < 0.05 vs. before ATP.