Fig. 3.

HKα₁^−/− mice have impaired dipsogenic response to a high-Na⁺ (HS) diet. A: water bottle intake in WT and HKα₁^−/− mice shown normalized for body weight. B: urine osmolality. C: urinary Na excretion. D: Na⁺ retention calculated as the difference between Na⁺ intake and urinary output. E: change in body weight. *P < 0.05, WT vs. HKα₁^−/−, Tukey's test; **P < 0.001 NS vs. HS within same genotype, one-way repeated-measures ANOVA. †P < 0.001 normal-Na⁺ diet (NS) vs. HS within WT only, one-way repeated-measures ANOVA. All data are shown as means ± SE for days 5–7 of NS and days 1–7 of HS. WT (n = 6–7); K HKα₁^−/− (n = 6). Solid lines, WT; dotted lines, HKα₁^−/−.