Table 1.

Metabolic balance data of wild-type and HKα₁^−/− mice on a normal (0.32%) and high- (2.0%) Na diet

	Normal Na		High Na, Day 1		High Na, Day 7
	Wild Type	HKα1−/−	Wild Type	HKα1−/−	Wild Type	HKα1−/−
Food intake/body weight, g/g	0.34 ± 0.01	0.34 ± 0.01	0.35 ± 0.01	0.34 ± 0.01	0.28 ± 0.01	0.32 ± 0.01*
Fluid balance, ml/g	0.16 ± 0.02	0.16 ± 0.01	0.23 ± 0.02†	0.17 ± 0.01*	0.21 ± 0.01	0.21 ± 0.01
Na intake, mg·day−1·g−1	0.50 ± 0.02	0.49 ± 0.01	3.1 ± 0.1†	3.1 ± 0.1†	2.5 ± 0.1†	2.9 ± 0.1*
Urine volume, ml/day	3.4 ± 0.5	3.4 ± 0.3	8.0 ± 1.0†	4.7 ± 0.3*†	5.3 ± 0.3	5.9 ± 0.5

Data are shown as means ± SE; wild type, n = 7; knockout of the HKα₁ isoform of H⁺,K⁺-ATPase (HKα₁^−/−), n = 6.

^*P < 0.05 vs. wild type, same day;

^†P < 0.05 vs. normal Na, same genotype.