Table 5.
Model variables at baseline: interstitial pressures and concentrations; initial pressures and flows
| MR(0) | MR(1) | OM(0) | OM(1) | OM(2) | IM(1) | IM(2) | IM(3) | IM(4) | IM(5) | |
|---|---|---|---|---|---|---|---|---|---|---|
| Interstitial pressures and concentrations | ||||||||||
| PS, mmHg | 12.0 | 5.2 | 12.0 | 9.1 | 9.6 | −2.3 | −2.0 | −1.1 | 0.9 | −1.3 |
| CS, mM | ||||||||||
| Na | 144.0 | 148.0 | 144.0 | 158.7 | 173.8 | 175.0 | 175.0 | 174.2 | 172.9 | 177.7 |
| K | 5.0 | 8.0 | 5.0 | 10.2 | 15.0 | 17.1 | 17.1 | 16.8 | 16.7 | 17.1 |
| Cl | 118.6 | 131.0 | 118.6 | 143.6 | 163.1 | 175.2 | 178.2 | 178.6 | 178.0 | 183.1 |
| HCO3 | 25.0 | 23.5 | 25.0 | 23.0 | 24.7 | 16.1 | 13.4 | 12.0 | 11.3 | 11.4 |
| H2CO3 | 4.4E-03 | 7.2E-03 | 4.4E-03 | 6.5E-03 | 1.2E-02 | 1.1E-02 | 1.1E-02 | 1.1E-02 | 1.2E-02 | 1.2E-02 |
| CO2 | 1.5 | 2.5 | 1.5 | 2.2 | 4.0 | 3.8 | 3.8 | 3.9 | 4.0 | 4.1 |
| HPO4 | 2.0 | 1.0 | 2.0 | 1.3 | 0.8 | 0.7 | 0.7 | 0.6 | 0.6 | 0.6 |
| H2PO4 | 0.6 | 0.5 | 0.6 | 0.6 | 0.7 | 0.8 | 0.9 | 1.0 | 1.0 | 1.0 |
| Urea | 5.0 | 7.3 | 5.0 | 8.6 | 8.9 | 13.2 | 17.9 | 27.9 | 58.5 | 56.1 |
| NH3 | 2.9E-03 | 1.3E-02 | 2.9E-03 | 1.3E-02 | 9.0E-03 | 6.8E-03 | 6.1E-03 | 5.4E-03 | 5.0E-03 | 5.0E-03 |
| NH4 | 0.2 | 1.5 | 0.2 | 1.4 | 1.6 | 1.8 | 1.9 | 2.0 | 2.0 | 2.0 |
| HCO2 | 1.0 | 0.5 | 1.0 | 0.5 | 0.4 | 0.3 | 0.2 | 0.2 | 0.1 | 0.1 |
| H2CO2 | 2.7E-04 | 2.6E-04 | 2.7E-04 | 2.4E-04 | 2.7E-04 | 3.0E-04 | 2.7E-04 | 2.4E-04 | 1.9E-04 | 1.5E-04 |
| Glucose | 5.0 | 2.8 | 5.0 | 2.8 | 2.1 | 1.7 | 1.4 | 1.1 | 0.8 | 0.7 |
| Osmolality | 307.9 | 326.7 | 307.9 | 352.9 | 395.1 | 405.9 | 410.5 | 418.1 | 445.8 | 453.9 |
| Vessel Po2, mmHg | 65 | 35 | 35 | 35 | 35 | 35 | 35 | 13 | 10 | 7 |
| SF | JM-1 | JM-2 | JM-3 | JM-4 | JM-5 | CNT | |
| Initial pressures and flows | |||||||
| SNGFR, nl/min | 29.2 | 58.9 | 58.9 | 59.0 | 59.7 | 59.6 | |
| Tubules | 24,000 | 6,400 | 3,200 | 1,600 | 800 | 400 | |
| GFR, μl/min | 701 | 377 | 189 | 94 | 48 | 24 | |
| PM, mmHg | 12.0 | 12.2 | 12.7 | 13.1 | 13.6 | 14.1 | 6.9 |