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. 2018 Jul 26;19(10):1109–1116. doi: 10.1093/ehjci/jey095

Table 2.

Mitral valve characteristics of control, subclinical HCM, and overt HCM cohorts

Controls (n = 63) Subclinical HCM (n = 79) Overt HCM (n = 50) P-value for global test P-valuea, control vs. subclinical P-valuea, control vs. overt P-valuea, subclinical vs. overt
MV annular diameter at end diastole (mm) 34.6 ± 0.4 33.9 ± 0.4 37.5 ± 0.7 0.002 0.29 0.0008 <0.0001
Anterior MV leaflet characteristics
 ALL (mm) 29.1 ± 0.5 29.9 ± 0.5 31.7 ± 0.5 0.0008 0.21 0.0002 0.014
 Anterior leaflet thickness (mm) 1.34 ± 0.06 1.41 ± 0.08 1.76 ± 0.09 0.030 0.45 0.0003 0.009
 ALL/BSAb (mm/m2) 16.0 ± 0.4 17.1 ± 0.4 17.9 ± 0.4 0.006 0.018 0.002 0.11
 ALL/LVEDVib (mm/ mL/m2) 0.51 ± 0.02 0.57 ± 0.02 0.78 ± 0.04 <0.0001 0.013 <0.0001 <0.0001
 ALL/LVOT diameter 1.35 ± 0.02 1.42 ± 0.03 1.47 ± 0.03 0.006 0.015 0.001 0.21
Posterior MV leaflet characteristics
 PLL (mm) 15.3 ± 0.4 15.6 ± 0.4 18.2 ± 0.6 0.001 0.45 <0.0001 0.0002
 Posterior leaflet thickness (mm) 1.62 ± 0.07 1.79 ± 0.08 2.12 ± 0.09 0.013 0.059 <0.0001 0.012
 PLL/BSAb (mm/m2) 8.3 ± 0.3 8.8 ± 0.3 10.2 ± 0.4 <0.0001 0.11 <0.0001 0.001
 PLL/LVEDVib (mm/ mL/m2) 0.28 ± 0.01 0.30 ± 0.01 0.45 ± 0.02 0.0003 0.079 <0.0001 <0.0001
 PLL/LVOT diameter 0.71 ± 0.02 0.74 ± 0.02 0.84 ± 0.03 0.001 0.18 <0.0001 0.001
Papillary muscle (PM) characteristics
 H2: Papillary-septal separation (mm) 34.2 ± 0.9 31.1 ± 0.7 29.4 ± 0.8 0.007 0.004 <0.0001 0.033
 H1: Medio-lateral PM separation (mm) 17.6 ± 0.5 18.4 ± 0.6 20.0 ± 0.7 0.016 0.27 0.001 0.08
 Papillary-septal separation /LV internal diameter 0.71 ± 0.01 0.67 ± 0.01 0.64 ± 0.01 0.010 0.011 <0.0001 0.065
Mitral regurgitation (MR)c
 None 36 (57.1%) 40 (50.6%) 11 (22.0%) 0.048 0.17 0.08 0.09
 Trace 25 (39.7%) 37 (46.8%) 30 (60.0%)
 Mild 2 (3.2%) 1 (1.3%) 7 (14.0%)
 Moderate 2 (4.0%)
 Severe

Values expressed as mean adjusted for age, sex, family relations, and BSA ± standard error, unless otherwise stated.

ALL, anterior leaflet length; BSA, body surface area; LVEDVi, LV end-diastolic volume indexed for BSA; LVOT, left ventricular outflow tract; MV, mitral valve; PLL, posterior leaflet length.

a

P-values reflect adjustment for age, sex, BSA, and family relations unless otherwise stated. A P-value <0.017 was considered statistically significant.

b

BSA was not included in multivariable models given that BSA was already incorporated in the dependent variable.

c

MR could not be evaluated in 1 (1.3%) patient in the subclinical HCM cohort.