Table 4.
Characteristics of synovial fluid from patients with rheumatoid arthritis and osteoarthritis
| Rheumatoid arthritis (n = 10) | Osteoarthritis (n = 11) | P value | |
|---|---|---|---|
| Age (years) | 55 ± 13 | 69 ± 19 | 0.055 |
| Female (%) | 60 | 55 | 1.0 |
| SF total WBC | 15,409 ± 6153 | 617 ± 496 | 0.001 |
| SF neutrophils | 11,840 ± 7000 | 120 ± 177 | 0.001 |
| SF monocytes/macrophages | 2074 ± 1490 | 247 ± 135 | 0.001 |
| HDL cholesterol | 18 ± 10 | 12 ± 7 | 0.12 |
| Total cholesterol | 59 ± 17 | 26 ± 17 | 0.0004 |
| HDL inflammatory index | 2.1 ± 1.9 | 0.5 ± 0.1 | 0.046 |
| MPO activity (ng/ml) | 74.5 ± 48.3 | 0.9 ± 0.6 | 0.008 |
| Aryl activity (μmol/min/ml) | 412 ± 150 | 122 ± 129 | 0.001 |
| PON1 activity (nmol/min/ml) | 87 ± 37 | 39 ± 19 | 0.004 |
| 5HETE (ng/ml SF) | 0.44 ± 0.33 | 0.57 ± 0.68 | 0.97 |
| 12HETE (ng/ml SF) | 0.12 ± 0.07 | 0.12 ± 0.05 | 0.86 |
| 15HETE (ng/ml SF) | 0.37 ± 0.07 | 0.26 ± 0.11 | 0.02 |
| 9HODE (ng/ml SF) | 1.31 ± 1.70 | 0.63 ± 0.36 | 0.27 |
| 13HODE (ng/ml SF) | 4.15 ± 4.20 | 2.02 ± 1.20 | 0.096 |
SF synovial fluid, WBC white blood cell, HDL high density lipoprotein, MPO myeloperoxidase, Aryl arylesterase, PON1 paraoxonase, HETE hydroxyeicosatetraenoic acid, HODE hydroxyoctadecadienoic acid