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. Author manuscript; available in PMC: 2018 Sep 21.
Published in final edited form as: Nat Rev Neurosci. 2018 Sep;19(9):535–551. doi: 10.1038/s41583-018-0039-7
Classic PTSD Dissociative identity disorder PTSD dissociative subtype
Responses to tra urn a-related cues characterized by Responses to trauma-related cues fluctuate between classic and dissociative subtype neurobiological patterns Responses to trauma-related cues characterized by
• intrusive re-experiencing symptoms • symptoms of detachment and numbness
• behavioural activation
• increased physiological arousal • behavioural deactivation
• increased amygdala and insula activation • decreased and/or maintained physiological arousal
• decreased vmPFC activation • decreased amygdala and insula activation
• increased vmPFC activation