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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Anesthesiology. 2018 Oct;129(4):744–755. doi: 10.1097/ALN.0000000000002368

Figure 5. A–D. Dose response for ketamine using Loss of Righting Reflex (LORR) in global and cell-specific Ndufs4(KO) mice (A–D) compared to control mice.

Figure 5

Each graph shows the dose response curves to intraperitoneal ketamine for control (red) and KO (blue) mice as well as the related with variable slope and the interpolated curve fits (magenta, green solid lines) with the 95% confidence intervals (magenta, green dotted lines). A. Global Ndufs4(KO) mice compared to control mice. N=12 for the KO and 11 for controls. B. Ndufs4(KO) restricted to VGLUT2-positive glutamatergic neurons (VGLUT2-(KO) compared to control. N=7 for each genotype. C. Ndufs4(KO) restricted to GABAergic neurons (GABA-(KO) compared to control. N=7 for GABAergic KO, 15 for controls. D. Ndufs4(KO) restricted to cholinergic neurons (CHAT-(KO) compared to control. N=6 for each genotype.