Table 1.
Effect of compounds on the inhibition of TNF‐α released by LPS induction from J774A.1 cells.
Compound | Structure | TNF‐α inhibition IC50 [μm] |
---|---|---|
6 |
![]() |
29 |
7 |
![]() |
50 |
8 |
![]() |
>90 |
9 |
![]() |
>90 |
10 |
![]() |
13 |
11 |
![]() |
33 |
12 |
![]() |
>90 |
13 |
![]() |
>90 |
14 |
![]() |
37 |
15 |
![]() |
>90 |
16 |
![]() |
>90 |
17 |
![]() |
>90 |
18 |
![]() |
>90 |
19 |
![]() |
40 |
20 |
![]() |
>90 |
21 |
![]() |
>90 |
22 |
![]() |
>90 |
23 |
![]() |
>90 |
24 |
![]() |
32[a] |
25 |
![]() |
26[a] |
26 |
![]() |
>90 |
27 |
![]() |
29[a] |
[a] Compound showed cytotoxicity at this concentration.