. 2018 Sep 17;6:e5665. doi: 10.7717/peerj.5665

Table 3. Univariate and multivariate analyses of OS rates in the 169 stage 3 and 4 patients by Cox regression model.

Variable		Univariate analysis			Multivariate analysis
		P	HR	95% CI	P	HR	95% CI
Age	12 months		1			1
	12–60 months	.022	2.729	1.159–6.426	.544	.674	.188–2.410
	≥60 months	.039	2.594	1.049–6.415	.599	.691	.174–2.743
Sex (Female vs. male)		.709	.914	.570–1.466	.968	1.010	.616–1.657
Site	Adrenal gland		1
	Mediastinum	.130	.524	.227–1.210
	Others	.868	.918	.334–2.524
INSS stage (4 vs. 3)		.002	2.451	1.408-4.266	.262	1.398	.778-2.512
Risk group(High-risk vs. intermediate-risk)		.000	10.005	3.140–31.873	.007	7.829	1.752–34.983
Grade of differentiation	Undifferentiated subtye		1			1
	Poorly differentiated subtype	.005	.519	.330–.817	.794	.931	.546–1.587
	Differentiating subtype	.035	.118	.016–.863	.807	.735	.062–8.695
FH/UH (FH vs UH)		.003	.313	.143–.682	.874	1.110	.308–3.996
MYCN status (Unamplificaction vs. amplification)		.000	.247	.154–.394	.001	.357	.196-.651
ASCT (No vs. yes)		.193	1.557	.799–3.032
Radiation (No vs. yes)		.105	.678	.423–1.085
Surgical methods(STR vs. GTR)		.011	1.794	1.143–2.817	.047	1.590	1.006–2.513

Notes.

Abbreviations