Table 2.
Entry a | Reaction time / h | organic phase | The amount of solvent / mL | Yield b / % |
1 | 1 | CHCl3 | 10 | 25.5 |
2 | 1 | C6H6 | 10 | 45.2 |
3 | 1 | CH3COOEt | 10 | 54.3 |
4 | 1 | Toluene | 10 | 83.0 |
a Reaction conditions: A mixture of quinazolin-4-one (1 mmol) (2e), 1-bromopropane (1.0 mmol), Bu4NBr (0.08 mmol), 35 % potassium hydroxide (84 mmol, 10mL) in toluene (10 mL) was stirred at 88-90°C for 1 h. b Yields of isolated products.