Table 2.

Nucleophilic substitution of 6-fluoroquinoxalines with amines and nitrogen-containing aromatic heterocycles.

Entry	Compound	R1	NR2R3	Yield (%)a
1	3	H	Pyrrolidine	93
2	4	H	Piperidine	85
3	5	H	4-Methoxybenzylamine	45
4	6	H	Imidazole	92b
5	7	H	Pyrazole	88b
6	8	Methyl	Pyrrolidine	88c
7	9	Methyl	Piperidine	50c
8	10	Methyl	Imidazole	88
9	11	Methyl	Pyrazole	88
10	12	2-Furyl	Pyrrolidine	93
11	13	2-Furyl	Piperidine	90
12	14	2-Furyl	Homopiperidine	73
13	15	2-Furyl	4-Methoxybenzylamine	80
14	16	2-Furyl	Pyrrole	94
15	17	2-Furyl	Imidazole	97
16	18	2-Furyl	Pyrazole	97
17	19	4-Methylphenyl	Pyrrolidine	90c
18	20	4-Methylphenyl	Homopiperidine	50c
19	21	4-Methylphenyl	Pyrrole	96
20	22	4-Methylphenyl	Pyrazole	96

^a Isolated yields of pure compounds.

^b Microwave irradiation, 200 ^oC, 5 min

^c Microwave irradiation, 200 ^oC, 60 min