Table 2.
Two-Point Lod Scores for the Severe Pediatric GER Locus and Microsatellite Markers on Chromosome 13q for Family L (Families 2, 3, and 4)*
| Microsatellite Marker | Map Distance, cM | Recombination Fraction, θ | ||||||
|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 5 | 10 | 20 | 30 | 40 | ||
| D13S175 | 6 | −1.79 (−2.08) | −1.39 (−1.70) | −0.68 (−0.99) | −0.31 (−0.59) | 0.00 (−0.23) | 0.09 (−0.08) | 0.08 (−0.02) |
| D13S217 | 17 | −2.14 (−2.31) | −1.61 (−1.76) | −0.75 (−0.93) | −0.27 (−0.49) | 0.09 (−0.11) | 0.14 (0.00) | 0.08 (0.02) |
| D13S171 | 25 | −0.36 (−0.33) | −0.24 (−0.29) | 0.01 (−0.17) | 0.13 (−0.07) | 0.18(0.02) | 0.15 (0.05) | 0.09 (0.04) |
| D13S218 | 33 | 2.03 (1.64) | 2.00 (1.61) | 1.85 (1.47) | 1.65 (1.30) | 1.24 (0.94) | 0.81 (0.57) | 0.37 (0.22) |
| D13S1288 | 34 | 4.05 (3.58) | 3.97(3.51) | 3.68 (3.23) | 3.30 (2.87) | 2.49(2.11) | 1.63 (1.31) | 0.75 (0.51) |
| D13S1253 | 35 | 3.26 (2.79) | 3.20 (2.73) | 2.95 (2.50) | 2.63 (2.21) | 1.97 (1.61) | 1.28 (0.98) | 0.59 (0,36) |
| D13S263 | 38 | 4.05 (3.58) | 3.97(3.51) | 3.68 (3.23) | 3.30 (2.87) | 2.49 (2.11) | 1.63 (1.31) | 0.75 (0.51) |
| D13S1297 | 39 | 2.29 (1.86) | 2.25 (1.81) | 2.06 (1.63) | 1.82 (1.41) | 1.31 (0.94) | 0.80 (0.50) | 0.33 (0.16) |
| D13S1272 | 42 | 2.06(1.62) | 2.03 (1.59) | 1.88 (1.46) | 1.68 (1.28) | 1.25 (0.91) | 0.79 (0.53) | 0.35 (0.19) |
| D13S153 | 46 | 1.34 (0.90) | 1.29 (0.86) | 1.19(0.79) | 1.16(0.79) | 0.99 (0.70) | 0.68 (0.46) | 0.32 (0.18) |
| D13S155 | 46 | −0.26 (−0.46) | −0.12 (−0.39) | 0.16 (−0.19) | 0.38 (0.02) | 0.54 (0.21) | 0.45(0.19) | 0.24 (0.09) |
| D13S1296 | 53 | −2.13 (−2.21) | −1.76 (−1.93) | −0.87 (−1.17) | −0.31 (−0.63) | 0.16 (−0.12) | 0.28 (0.06) | 0.20 (0.07) |
| D13S156 | 56 | −2.29 (−2.40) | −1.95 (−1.98) | −1.34 (−1.25) | −0.97 (−0.83) | −0.54 (−0.38) | −0.25 (−0.14) | −0.07 (−0.03) |
| D13S170 | 65 | −2.07 (−2.06) | −1.78 (−1.75) | −1.27 (−1.17) | −0.94 (−0.83) | −0.47 (−0.41) | −0.15 (−0.15) | 0.00 (−0.02) |
| D13S265 | 71 | −2.23 (−2.39) | −1.86 (−1.98) | −1.31 (−1.30) | −0.97 (−0.88) | −0.53 (−0.39) | −0.24 (−0.14) | −0.07 (−0.03) |
| D13S159 | 74 | −2.12 (−2.41) | −1.85 (−2.15) | −1.36 (−1.63) | −0.99 (−1.23) | −0.47 (−0.65) | −0.16 (−0.29) | −0.02 (−0.08) |
| D13S158 | 82 | −0.86 (−1.00) | −0.83 (−0.91) | −0.73 (−0.65) | −0.62 (−0.42) | −0.42 (−0.17) | −0.24 (−0.06) | −0.09 (−0.01) |
| D13S173 | 96 | −2.03 (−2.19) | −1.76 (−1.96) | −1.18 (−1.43) | −0.65 (−0.92) | −0.04 (−0.30) | 0.18 (−0.03) | 0.17 (0.04) |
| D13S1265 | 102 | −1.29 (−1.35) | −1.25 (−1.32) | −1.01 (−1.12) | −0.61 (−0.78) | −0.05 (−0.26) | 0.16 (−0.03) | 0.16 (0.03) |
| D13S285 | 113 | −3.67 (−3.71) | −3.13 (−3.19) | −2.12 (−2.23) | −1.41 (−1.54) | −0.57 (−0.70) | −0.16 (−0.26) | 0.00 (−0.06) |
Lod indicates logarithm of odds; GER, gastroesophageal reflux; and cM, centimorgan. Data are lod scores unless otherwise indicated. For each value of θ for each microsatellite marker, the first lod score shown resulted from running the Linkage program with all presumptively affected individuals (ie, those whose informal medical history indicated severe pediatric GER but who were not definitively diagnosed by a physician) modeled as “unknown” phenotype, a conservative assumption. The second lod score in each cell, in parentheses, resulted from rerunning Linkage with a worst-case assumption, in which all presumptively affected individuals were modeled as “unaffected” phenotype. Lod scores of 3.0 or greater are shown in boldface. Distances in cM are rounded to the nearest whole number.