Table 3.
Multifamily 2-Point Lod Scores for the Severe Pediatric GER Locus on Chromosome 13q at θ = 0*
| Microsatellite Marker | Map Distance, cM | Family | |||||||
|---|---|---|---|---|---|---|---|---|---|
| 2&3 | 4 | 2&3 + 4 | 2&3&4 | 1 | 5 | 2&3 + 4 + 1+5 | 2&3&4 + 1+5 | ||
| D13S175 | 6 | −0.69 | −0.97 | −1.66 | −1.79 (−2.08) | 0.00 (0.00) | 0.00 (0.00) | −1.66 | −1.79 (−2.08) |
| D13S217 | 17 | −1.70 | −1.18 | −2.88 | −2.14 (−2.31) | 0.00 (0.00) | 0.00 (0.00) | −2.88 | −2.14 (−2.31) |
| D13S171 | 25 | −0.64 | 0.00 | −0.64 | −0.36 (−0.33) | −0.65 (−1.19) | 0.17(0.08) | −1.12 | −0.84 (−1.44) |
| D13S218 | 33 | 2.10 | 0.00 | 2.10 | 2.03 (1.64) | 1.03 (−0.63) | 0.46 (0.27) | 3.59 | 3.52 (1.28) |
| D13S1288 | 34 | 2.96 | 1.13 | 4.09 | 4.05 (3.58) | 0.17 (−1.14) | 1.06 (0.87) | 5.31 | 5.27 (3.31) |
| D13S1253 | 35 | 2.18 | 1.13 | 3.31 | 3.26 (2.79) | 0.46 (−0.41) | 1.81 (1.61) | 5.58 | 5.53 (3.99) |
| D13S263 | 38 | 2.96 | 1.13 | 4.09 | 4.05 (3.58) | 1.03 (−0.62) | −0.67 (−0.87) | 4.45 | 4.40 (2.09) |
| D13S1297 | 39 | 1.22 | 1.13 | 2.35 | 2.29 (1.86) | 0.73 (−0.70) | −0.73 (−0.60) | 2.36 | 2.30 (0.56) |
| D13S1272 | 42 | 2.14 | −0.01 | 2.13 | 2.06 (1.62) | 1.03 (−0.63) | −2.23 (−2.42) | 0.93 | 0.86 (−1.43) |
| D13S153 | 46 | 2.41 | −0.93 | 1.48 | 1.34 (0.90) | 0.44 (−0.77) | 0.00 (0.00) | 1.92 | 1.78 (0.13) |
| D13S155 | 46 | 0.46 | −0.93 | −0.48 | −0.26 (−0.46) | 1.03 (−0.30) | 0.00 (0.00) | 0.55 | 0.77 (−0.76) |
| D13S1296 | 53 | −1.51 | −1.08 | −2.59 | −2.13 (−2.21) | 0.00 (0.00) | −2.40 (−2.33) | −4.99 | −4.53 (−4.54) |
| D13S156 | 56 | −2.09 | 0.00 | −2.09 | −2.29 (−2.40) | 0.00 (0.00) | 0.00 (0.00) | −2.09 | −2.29 (−2.40) |
| D13S170 | 65 | −2.15 | −0.41 | −2.56 | −2.07 (−2.06) | 0.00 (0.00) | 0.00 (0.00) | −2.56 | −2.07 (−2.06) |
| D13S265 | 71 | −0.87 | −1.18 | −2.05 | −2.23 (−2.39) | 0.00 (0.00) | 0.00 (0.00) | −2.05 | −2.23 (−2.39) |
| D13S159 | 74 | −1.00 | −0.98 | −1.98 | −2.12 (−2.42) | 0.00 (0.00) | 0.00 (0.00) | −1.98 | −2.12 (−2.42) |
| D13S158 | 82 | −0.98 | 0.00 | −0.98 | −0.86 (−1.00) | 0.00 (0.00) | 0.00 (0.00) | −0.98 | −0.86 (−1.00) |
| D13S173 | 96 | −1.99 | −0.99 | −2.98 | −2.03 (−2.19) | 0.00 (0.00) | 0.00 (0.00) | −2.98 | −2.03 (−2.19) |
| D13S1265 | 102 | −1.21 | −1.01 | −2.21 | −1.29 (−1.35) | 0.00 (0.00) | 0.00 (0.00) | −2.21 | −1.29 (−1.35) |
| D13S285 | 113 | −2.54 | −1.01 | −3.54 | −3.67 (−3.71) | 0.00 (0.00) | 0.00 (0.00) | −3.54 | −3.67 (−3.71) |
Lod indicates logarithm of odds; θ, recombination fraction; cM, centimorgan; &, that the numbered families shown were analyzed together using the Linkage program with all available common ancestors included; and +, that the lod scores were arithmetically combined for the families shown after being run individually. Data are lod scores unless otherwise Indicated. In columns 6, 7, 8, and 10, the first lod score shown for each microsatellite marker resulted from running the program with all presumptively affected individuals modeled as “unknown” phenotype, and the second lod score (in parentheses) resulted from rerunning it with these individuals modeled as “unaffected.” Lod scores of 3.0 or greater are shown In boldface.