TABLE IV.

Overall Frequencies of Identified Polymorphisms in the 5-HT_1B Receptor Gene

SNPa	Nucleotide positionb	Location in gene	Previously reported allele frequency	This study overall allele frequency (n = 157)c
T-261G	−261	5′ untranslated region	49% (n = 46) [Nothen et al., 1994]	32.7%
−184/− 183 dinucleotide deletion	−182, −181	5′ untranslated region	Not previously reported	0.6%
−182/− 181 dinucleotide deletion	−182, −181	5′ untranslated region	Not previously reportedd	2.9%
A-161T	−161	5′ untranslated region	Not previously reportedd	18.3%
C129T	129	N-terminal domain (synonymous)	17% (n= 178) [Huang et al., 1999]	26.8%
G861C	861	Intracellular loop III (synonymous)	23% (n = 640)e; 62% (n = 418)e [Lappalainen et al., 1995]; 26.8% 17% (n = 178) [Huang et al., 1999]	26.8%
A1180G	1180	3′ untranslated region	Not previously reportedd	5.8%

^aSNPs are named according to their position within the gene with the most commonly occurring nucleotide placed before the nucleotide position and the variant allelic nucleotide following the position.

^bNucleotide position is defined according to the numbering scheme that designates the first nucleotide of the start codon as position +1.

^cFor T-261G and A1180G, n = 156 due to ambiguous sequencing data from one subject for each allele, respectively; for A-161T, n=210 due to the genotyping of an additional 53 subjects at this position.

^dFollowing completion of the work for this study and submission of this article, these polymorphisms were found to be reposited in the National Center for Biotechnology Information SNP database, with an initial release date of 29 January, 2001. These polymorphisms have not previously been specifically reported in a scientific communication.

^eTwo separate ethnic populations were surveyed in this report.