TABLE VII.
Allele Distribution and Analysis of Common SNPs Stratified by Ethnicity and Grouped by Combined Drug Abuse and Dependence Categories*
| Cocaine | Alcohol | Controls | ||||
|---|---|---|---|---|---|---|
| T-261G(n=147) | T | G | T | G | T | G |
| Caucasian American | 16 (57.1%) | 12 (42.9%) | 20 (55.6%) | 16 (44.4%) | 32 (57.1%) | 24 (42.9%) |
| African American | 56 (84.8%) | 10 (15.2%) | 10 (83.3%) | 2 (16.7%) | 34 (68.0%) | 16 (32.0%) |
| Hispanic American | 9 (75.00%) | 3 (25.00%) | 4 (50.0%) | 4 (50.0%) | 17 (65.4%) | 9 (34.6%) |
| Cocaine | Alcohol | Controls | ||||
| A-161T(n = 200) | A | T | A | T | A | T |
| Caucasian American | 30 (83.3%) | 6 (16.7%) | 27 (71.1%) | 11 (28.9%) | 58 (65.9%) | 30 (34.1%) |
| African American | 96 (92.3%) | 8 (7.7%) | 12 (100.0%) | 0 (0.0%) | 66 (94.3%) | 4 (5.7%) |
| Hispanic American | 15 (83.3%) | 3 (16.7%) | 4 (50.0%) | 4 (50.0%) | 18 (69.2%) | 8 (30.8%) |
| Cocaine | Alcohol | Controls | ||||
| C129T/G861C(n=148) | C | T | C | T | C | T |
| Caucasian American | 19 (67.9%) | 9 (32.1%) | 23 (60.5%) | 15 (39.5%) | 37 (66.1%) | 19 (33.9%) |
| African American | 53 (80.3%) | 13 (19.7%) | 8 (66.7%) | 4 (33.3%) | 44 (88.0%) | 6 (12.0%) |
| Hispanic American | 9 (75.0%) | 3 (25.0%) | 5 (62.5%) | 3 (37.5%) | 17 (65.4%) | 9 (34.6%) |
Individuals of mixed ethnicity are not included in calculations. Pooled Relative Risk (RR) and Mantel-Haenszel Chi-square test on combined cocaine abuse and dependence and control subjects stratified by ethnicity are as follows. For T-261G, RR (cocaine vs. controls) =1.63, Chi-square =2.26, P =0.133. For A-161T, RR (cocaine vs. controls) = 1.72, Chi-square = 2.13, P = 0.145. For C129T/G861C, RR (cocaine vs. controls) =0.90, chi-square =0.032, P = 0.857. Pooled relative risk and Mantel-Haenszel chi-square test on combined alcohol abuse and dependence and control subjects stratified by ethnicity are as follows. For T-261G, RR (alcohol vs. controls) =1.02, Chi-square =0.01, P =0.919. For A-161T, RR (alcohol vs. controls) =1.11, Chi-square =0.01, P =0.922. For C129T/G861C, RR (alcohol vs. controls =0.66, Chi-square =1.12, P =0.291.