Table 1.
Clinical Features and Laboratory Values
| Patient 1 | Patient 2 | |
|---|---|---|
| Year of HIV diagnosis | 2005 | 2009 |
| HIV risk group | MSM | MSM |
| CD4+ cells/μL (%) at HIV diagnosis | 487 (17%) | 285 (16%) |
| HIV RNA copies/mL at HIV diagnosis | 61,074 | 1,180,316 |
| Nadir CD4+ cells/μL (%) | 219 (15%) | 196 (22%) |
| Zenith HIV RNA copies/mL | 534,955 | 1,180,316 |
| Antiretroviral regimen | Emtricitabine/tenofovir+ atazanavir/ritonavir | Emtricitabine/tenofovir+ atazanavir/ritonavir |
| Months of antiretroviral treatment at diagnosis of multicentric Castleman disease | 58 | 19 |
| Status at the time of multicentric Castleman disease diagnosis | ||
| CD4+ cells/μL (%) | 895 (28%) | 171 (21%) |
| HIV RNA copies/mL | <40 | 110 |
| HHV8 DNA copies/mL | 38 | 958,962 |
| HHV8 Ab (lytic antigen) | 256 | 4,096 |
| HHV8 Ab (latency antigen) | 256 | 512 |
| KS lesions site (number) | Skin (10) | None |
| Maximum diameter of enlarged lymph nodes (mm) | ||
| • Submandibular (15) | • Neck (25) | |
| • Neck (20) | • Supra- and | |
| • Subclavian (20) | subclavian (28) | |
| • Axilla (20) | • Axilla (40) | |
| • Mediastinum (15) | • Abdomen (coeliac, para-aortic, iliac) (34) | |
| • Abdomen (coeliac, para-aortic, iliac) (20) | • Groin (20) | |
| • Groin (15) | ||
| Spleen diameter (cm) | 15 | 18 |
| Histopathogenic type | Hyaline-vascular | Plasmablastic |
HHV8 DNA was assessed with real-time polymerase chain reaction in plasma; antibodies to IgG anti-HHV8 lytic/latency antigens detected by immunofluorescence assay.
MSM indicates men who have sex with men; Ab, antibody; HHV8, human herpesvirus 8; lgG, immunoglobulin G; KS, Kaposi sarcoma.