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. 2018 Sep 21;22:221. doi: 10.1186/s13054-018-2137-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Algorithm for calculating regional time constant τ _reg. Of note, curve fitting starts at the time when 75% of peak signal is reached (see “Methods”). V(t): volume at time point t, V₀ volume at start of expiration, t the time from the start at end-inspiration to the end of expiration, τ the expiratory time constant and C the end expiratory volume