Table 3.

Comparison to familial lung cancer study using the recently published susceptible loci in OncoArray lung cancer

Strata	Chromosome	SNP	Position	Gene	Allelea	EAF	OR (95%CI)	P-value
Lung	1p31.1	rs71658797	77967507	FUBP1	T_A	0.099	1.12 (0.99–1.27)	7.54 × 10−2
Lung	6q27	rs6920364	167376466	RNASET2	G_C	0.449	1.08 (1.00–1.17)	5.25 × 10−2
Lung	8p21.1	rs11780471	27344719	EPHX2, CHRNA2	G_A	0.063	0.80 (0.67–0.95)	1.00 × 10−2
Lung	13q13.1	rs11571833	32972626	BRCA2	A_T	0.010	1.66 (1.14–2.41)	7.78 × 10−3
Lung	15q21.1	rs66759488	47577451	SEMA6D	G_A	0.362	1.05 (0.97–1.14)	1.91 × 10−1
Lung	15q25.1	rs55781567	78857986	CHRNA5	C_G	0.366	1.31 (1.21–1.41)	1.69 × 10−11
Lung	19q13.2	rs56113850	41353107	CYP2A6	C_T	0.429	0.91 (0.83–0.99)	2.86 × 10−2
Adeno	3q28	rs13080835	189357199	TP63	G_T	0.489	0.96 (0.86–1.08)	5.28 × 10−1
Adeno	5p15.33	rs7705526	1285974	TERT	C_A	0.343	1.28 (1.13–1.46)	1.45 × 10−4
Adeno	8p12	rs4236709	32410110	NRG1	A_G	0.225	1.10 (0.96–1.26)	1.56 × 10−1
Adeno	9p21.3	rs885518	21830157	MTAP/CDNK2A	A_G	0.110	1.37 (1.16–1.62)	2.20 × 10−4
Adeno	10q24.3	rs11591710	1.06E+08	OBFC1	A_C	0.143	1.14 (0.97–1.33)	1.21 × 10−1
Adeno	11q23.3	rs1056562	1.18E+08	MPZL3/AMICA1	C_T	0.471	1.08 (0.96–1.21)	1.89 × 10−1
Adeno	15q21.1	rs77468143	49376624	SECISBP2L	T_G	0.249	0.87 (0.76–0.99)	4.00 × 10−2
Adeno	20q13.33	rs41309931	62326579	RTEL1	G_T	0.119	1.35 (1.14–1.60)	6.14 × 10−4
SQC	6p21.33	rs116822326	31434111	MHC	A_G	0.161	1.26 (1.03–1.54)	2.36 × 10−2
SQC	12p13.33	rs7953330	998819	RAD52	G_C	0.313	0.79 (0.66–0.94)	7.05 × 10−3
SQC	22q12.1	rs17879961	29121087	CHEK2	A_G	0.004	2.50 (0.76–8.15)	1.29 × 10−1

EAF, effective allele frequency; OR, odds (log additive) ratio; 95% CI, 95% confidence interval; Adeno, adenocarcinoma; SQC, squamous cell carcinoma.

^aDenotes reference_effect(coded) allele. Variants in bold are associated with familial lung cancer at nominal significance level of 0.05. Genome positions relative to GRCh37.