Fig. 1.

Strategy of analysis of genes correlated with MUC4 expression in Cancer Cell Line Encyclopedia. a Flowchart of MUC4 analysis. MUC4 mRNA expression z-scores were extracted from Cancer Cell Line Encyclopedia using cBioportal. The list of gene correlated with MUC4 expression was determined by using the co-expression tool. Genes presenting a Pearson’s correlation higher than 0.3 or lower than − 0.3 were selected. Spearman analysis was performed subsequently. Gene ontology annotation and clustering were performed using DAVID 6.8 functional annotation tool. b Example of MUC4-MUC16 correlation of mRNA expression. c Example of MUC4-MUC20 correlation of mRNA expression