Fig. 3.

(A) Heart cross-section showing severe mitral annular calcification with infiltration areas in the posterior wall (arrow). (B) Transthoracic echocardiogram showed severe calcification of the mitral annulus and valvular subapparatus (arrow). (C) Histopathology cohort of material obtained from mitral valve subapparatus, showing the presence of acellular and amorphous material, similar to atheroma, with calcification and osteoclast-type giant cells, (D) comparable to that found in left main coronary artery. (E) Distal coronary microvasculature with the same embolized material.